(CNN)-Joaquin "El Chapo" Guzman, the boss of one of Mexico's most powerful drug trafficking operations, was arrested in Mexico, a U.S. official told CNN Saturday.
The official said Guzman, accompanied by a female, was captured in a joint operation with Mexican marines and Drug Enforcement Administration authorities overnight at a hotel in the beach resort of Mazatlán.
The operation had been in the works for four or five weeks, the official said.
Guzman, who authorities say has eluded capture for years, is wanted in the United States on multiple federal drug trafficking charges and last year was named a Public Enemy No. 1 by the Chicago Crime Commission.
His nickname, which means "Shorty," matches his 5-foot-6-inch frame.
Guzman escaped from a high-security Mexican prison in 2001 and avoided being caught because of his enormous power to bribe corrupt local, state and federal Mexican officials.
Since 2009, Guzmán has been included in Forbes' World's Most Powerful People list.